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10.1093/toxsci/kfx230 37 WeiM.GuX.LiH.ZhengZ.QiuZ.ShengY.et al (2023)

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Initial concerns were raised after findings from the cardiovascular outcome trial (CVOT), Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes 6 (SUSTAIN 6), revealed a greater risk of DR-related complications, defined as the need for laser therapy, intravitreal injections, development of vitreous hemorrhage, and blindness, in semaglutide users compared to placebo (3.0% vs 1.8%, HR=1.76, P =.02)

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And then the second component of my thinking about this, and as you pointed out, the gold standard and science is reproducibility