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Des facteurs, comme une activit physique importante ou certaines pathologies, peuvent acclrer sa diminution
Moreover, the growth factor amphiregulin interacts with IGF-IR and promotes the binding of IGF-IR to importin-1 thereby enhancing the nuclear translocation of IGF-IR [84]
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This targeted approach not only enhances the efficiency of growth hormone secretion but also minimizes potential side effects associated with non-specific stimulation
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