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In another study using HT22 cells, huperzine A (HupA) + wortmannin treatment stopped the downregulation of p-mTOR, p-Akt, and p-p70s6 kinase under oxidative glutamate toxicity, leading to the conclusion that HupA abrogates oxidative glutamate toxicity in mouse hippocampal cells via the activation of the BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway 51

To prevent the downstream effect of zonulin binding to its receptors after intestinal gliadin exposure, it is proposed that LA antagonizes the zonulin pathway by competitively inhibiting zonulin binding to target receptors, but further mechanistic studies are needed in order to support this proposal (Fig

Thus, despite the similarity in functions and morphological signs, eryptosis and apoptosis differ in signaling pathways

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Protein acetylation and acetyl coenzyme a metabolism in budding yeast