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Serious side effects are extremely uncommon

Fourth, anti-inflammatory and weight-loss-mediated pleiotropic effectsincluding reduction of systemic and pulmonary inflammation, improved respiratory mechanics with adiposity reduction, and microbiome-mediated changes in mucosal immunitymay explain the protective pneumonia signal in large real-world cohorts, though this mechanism requires prospective validation [11]

Large meals late at night can cause discomfort due to slowed gastric emptying

The most common cause of melanosis coli is the extended use of laxatives, and commonly anthraquinone containing laxatives such as Senna and other plant glycosides

10.1016/S2213-8587(18)30027-5 2 ArodaV