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In addition, increased p53 expression inhibits the expression of the system xc SLC7A11, resulting in reduced uptake of cystine, decreased GSH peroxidase activity, reduced cell antioxidant capacity, and increased sensitivity of cells to ferroptosis ( Neuropathological AD changes have been associated with impaired cerebral insulin signaling (Takeda et al., 2010
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J Biol Chem 285:4152532
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doi: 10.1007/s12020-021-02730-0 Summary Keywords growth hormone, insulin-like growth factor, GLP-1RAs, SGLT-2is, diabetes Citation Cignarelli A, Genchi VA, Le Grazie G, Caruso I, Marrano N, Biondi G, DOria R, Sorice GP, Natalicchio A, Perrini S, Laviola L and Giorgino F (2022) Mini Review: Effect of GLP-1 Receptor Agonists and SGLT-2 Inhibitors on the Growth Hormone/IGF Axis
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