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It's FDA-approved for Type-2 diabetes to improve glycemic control

On the Medicaid side, CMS launched the BALANCE model in December 2025, a voluntary five-year program for state agencies

The short duration requires consistent daily dosing, but most patients adapt quickly to the routine

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These differences affect how quickly inflammation appears and how outcomes are measured

Interestingly, RYGB controls 5-HT 2A receptor availability in the ventral striatum in rats [112], suggesting that GLP-1R agonists and bariatric surgery may both target the midbrain serotonergic system to exert their inhibitory effects on energy balance