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Mechanism of Action Comparison# Mazdutide# Mazdutide is designed as an analog of oxyntomodulin, a naturally occurring gut hormone that activates both GLP-1 and glucagon receptors

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In the SURPASS-2 trial, which compared it head-to-head against semaglutide 1 mg over 40 weeks, tirzepatide lowered HbA1c by about 2.0 to 2.3 percentage points across its 5, 10, and 15 mg doses, versus roughly 1.9 points for semaglutide, with greater weight loss as well

The STEP 2 trial [2] , which included participants with type 2 diabetes, showed slightly more modest but still substantial results, with 9.6% average weight loss compared to 3.4% with placebo

But the long term consequences are expected to cost far more, research published in JAMA Network Open suggests