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In fact, hydrogen peroxide can be generated directly by EGF binding to its cognate receptor (96), and overexpression of intracellular antioxidant enzymes, such as catalase, peroxiredoxins, or GPx-1, have been shown to interfere with cellular proliferation and growth factor-mediated responses by removing hydrogen peroxide essential for normal signaling responses (154, 269, 324)

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GHK-Cu is a copper-binding peptide discussed in the context of wound healing, tissue repair, and skin remodeling

While these conditions differ in underlying causes, both result in joint pain, stiffness, reduced mobility, and progressive tissue damage

Chun HJ, Kim YS, Kim BK, Kim EH, Kim JH, Do BR, Hwang SJ, Hwang JY, Lee YK: Transplantation of human adipose-derived stem cells in a rabbit model of traumatic degeneration of lumbar discs