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Comments: Renal function should be monitored when starting or escalating doses in patients with renal dysfunction reporting severe adverse GI reactions

Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR et al (2006) Caffeine protects Alzheimers mice against cognitive impairment and reduces brain beta-amyloid production

2023 Sep Koutatsu Maruyama, Ehab S Eshak, Minako Kinuta, Masanori Nagao, Renzhe Cui, Hironori Imano, Tetsuya Ohira, Hiroyasu Iso

The mechanism: KPV translocates into the cell nucleus and blocks the interaction between importin-alpha3 and the p65/RelA subunit of NF-kB, preventing p65 from reaching its transcriptional targets

The demonstrations that a native GS-like effector protein is secreted from the nematode, delivered into the host, translocated across the host plasma membrane, and localised within the host cell during parasitism are strong evidence of involvement in parasitism

Mike Israetel talks about a "Shameless Future" where body shame and remorse are relics of the past