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A 4 l drop of sample was applied to the grid and blotted with a Vitrobot Mark IV (Thermo Fisher Scientific) operating at 4C and 100% humidity, wait time of 10 s, blot time of 4 s, and blot force of 1, before plunge-freezing into liquid ethane

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Phase I study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors