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Gault VA, Holscher C

Relation of aspartate aminotransferase to Alanine aminotransferase ratio to nutritional status and prognosis in patients with acute heart failure

PIONEER 7 was a 52-week open-label trial that compared the efficacy and safety of once-daily oral semaglutide (with flexible-dose adjustment based on prespecified HbA1c and tolerability criteria to approximate treatment individualization in clinical practice) with the DPP-4 inhibitor sitagliptin, as an add-on to existing glucose-lowering medication (one or two oral antidiabetic agents, i.e., metformin, sulphonylureas, SGLT-2 inhibitors or thiazolidinediones), in patients with T2DM

DOI: 10.1172/JCI116186 [6] Coskun, T., Sloop, K.W., Loghin, C., et al

Impact of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of lenvatinib in patients with hepatocellular carcinoma

excess glutamate can theoretically lower the seizure threshold or trigger manic episodes in susceptible individuals