References Kojima, M
Gaetano Morelli, Chief Medical Officer at Altasciences
Sn phm c ngun gc ti M v n t thng hiu Puritans Pride
While Semaglutide represents a significant advancement in the management of diabetes and obesity, its interaction with thyroid function highlights the complexities of endocrine pharmacotherapy
The compound was first reported in Al-Obeidi, Castrucci, Hadley, and Hruby, J Med Chem 32 (12):255561 (1989) (PMID 2555512), building on the earlier open-chain superpotent precursor [Nle, D-Phe]--MSH reported by Sawyer, Sanfilippo, Hruby, Engel, Heward, Burnett, and Hadley in PNAS 77 (10):57548 (1980) (PMID 6777774)
This poses a serious challenge to the original concept of ferroptosis