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(a) Representative photomicrographs of Hematoxylin & Eosin and Massons trichrome staining (Olympus BX51, Tokyo, Japan

doi:10.3390/ijms221910498 95

Pregnancy and breastfeeding increase B12 requirements, and pregnant women with B12 deficiency may need more frequent monitoring and potentially adjusted treatment schedules

IFN- is responsible for macrophage activation, enhanced antigen presentation, and induction of nitric oxide-mediated killing mechanisms ( Our preclinical studies confirmed the previous findings that the T2DM group has lower levels of IFN- ( Figure 3E ) and TNF- ( Figure 3F ) when compared to healthy individuals

On really tough mornings, sipping a protein shake slowly over 30-60 minutes can work better than forcing down solid food