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Medical supervision helps reduce side effects and improve outcomes

In humans

Many melanocytomas are instead dermal-based, thick, combined melanocytic tumors in which an activating mutation of BRAF (or, much less commonly, NRAS ) is followed by a second genetic hit with expansion of a morphologically peculiar (non-classical) clone of melanocytes

Therefore, GSH could promote lipid accumulation or storage and support a TME that favors tumor growth [ 200 , 201 ]

However, these benefits were not maintained at 6 months, highlighting the need for longer-term studies in at-risk populations

Phase 2 studies showed therapeutic levels could be achieved in patients