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Some researchers find that starting at even lower doses than the clinical trial protocols and escalating more slowly can reduce the severity of gastrointestinal symptoms

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Lastly, gene expression analysis demonstrated that the molecular fingerprint of pathological cardiac hypertrophy was partly reversed by -MSH with a significant reduction in TAC-induced expression of fibrosis-related genes including Col1a2 (collagen type I, alpha 2) and Mmp2 (matrix metalloproteinase-2) (Appendix Fig