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A model was proposed to explain the distinct pharmacological properties of the two peptide agonists at the isolated NTD, with the suggestion that Ex4 formed an additional interaction (termed the Ex interaction), which was due to one or more of the unique structural features of Ex4, such as its increased helicity, its C-terminal extension, or residues that were not conserved with GLP-1 (Lpez de Maturana et al ., 2003)

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Patients taking antispasmodics (dicyclomine, hyoscyamine), fiber supplements, or gut-directed therapies should maintain these unless side effects become problematic

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