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Individuals with lower body fat may find the abdomen or thigh more suitable than the upper arm

Most Common Early Semaglutide Side Effects Nausea ranks as the most frequently reported side effect during the first two weeks of semaglutide treatment, affecting roughly 25 to 40 percent of users in clinical trials

Here's where the research stands now

Mol Cell Endocrinol (2015) 402:6471

These include specific kidney conditions such as distal renal tubular acidosis and medullary sponge kidney, gout, hyperparathyroidism, inflammatory bowel disease (particularly Crohn's disease), and recurrent urinary tract infections