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When the degradation of biogenic amines by DAO is dysregulated, histamine can accumulate and contribute to various intestinal pathologies [49]

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OSA patients who received tirzepatide initiated CPAP therapy about 83% less often than those who did not receive the drug

doi: 10.1016/S0140-6736(19)31149-3 [DOI] [PubMed] [Google Scholar] 255

Some suggest waiting at least 5 half-lives after holding the drug, which can mean days to weeks, depending on the formulation the patient uses

Escalation phase (roughly weeks 520): step up about every four weeks 5 7.5 10 12.5 15 mg but only as tolerated