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While correlative data such as these cannot establish causality, the observation that women are also more likely than men to discontinue these medications strengthens the interpretation that the efficacy-to-tolerability ratio for these drugs is lower for women (Fig

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One study in mice that compared GHK to GKH-Cu to copper alone noted that GHK-Cu was more effective than GHK alone in terms of antioxidant effect, and copper alone produced no benefit

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