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10.1016/j.tifs.2016.03.001 108 GonzalesG

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While not everyone with IgG4-RD experiences headaches, the disease can impact areas that lead to persistent or severe headaches, such as: The meninges: These protective brain layers can thicken and become inflamed (hypertrophic pachymeningitis), resulting in ongoing, sometimes debilitating headaches

These proteins possess intrinsically disordered stretches between the TMD and an intact folded functional domain, allowing flexible binding to an emerging substrate while modifying the substrate conformation to allow efficient ubiquitination