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Previous investigations have indicated that FGF21 may confer protection against diabetic cardiomyopathy by preserving mitochondrial function and inhibiting the accumulation of ROS

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found that circ_0001273, as a cancer-promoting factor that upregulates SLC1A5 expression by binding to miR-622, which increases Gln uptake by tumor cells, consequently enhancing tumor growth and inhibiting cell apoptosis (57)

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Copper modulates post-translational regulation of iron homeostasis, potentially by inhibiting Fe-S cluster biosynthesis, and transcriptionally upregulates key iron uptake genes, such as transferrin receptor 1