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Homocysteine reduces ATP production and cellular glucose consumption by inhibiting cytochrome C oxidase leading to more cellular injury (Zhai et al

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Due to the already sensitive nature of dopaminergic neurons to redox imbalance and ROS generation, the additional reduction of an antioxidant like GSH causes neuron loss (Smeyne and Smeyne, 2013)

Start with lower doses to assess tolerance, gradually increasing as appropriate