Many factors, such as the interruption of the estradiol cycle and the increase of inflammatory cytokines, will lead to changes in synaptic function and morphology, which may be one of the pathogenesis of depression (138)
The potencies observed in cellular assays show that it is a potent agonist at the GIP receptor, but exhibits balanced activity across GLP-1 and Glucagon receptors
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in mice exhibited decreased center time during the open field test (OFT), indicating increased anxiety-like behavior, as well as decreased sucrose preference, suggesting increased anhedonia (Mcgaughey et al., 2019)
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Besides, as mentioned above, early detection or intervention is crucial in minimizing the possibility of the malignant tumor formation (Subramaniam et al., 2014