A large-scale genome-wide association study published in Nature in April 2026, conducted by 23andMe researchers using data from 27,885 GLP-1 medication users, identified a specific variant in the GLP1R gene the gene that encodes the primary receptor these drugs target associated with differential weight loss efficacy
Results Semaglutide-induced weight loss results from reduced food consumption in ob/ob mice Eight-week-old male and female ob/ob mice were maintained on a standard chow diet for four weeks where their average body weight reached 50g and 52g for male and female respectively, after which they were treated with either 3 nmol/kg semaglutide or vehicle for three weeks (Figure 1A) and the food and body weight recorded daily
Rather than attempting three large meals, some patients may tolerate five to six smaller eating occasions better, distributing protein across the day
It can also help to go into those conversations with a few questions, such as: What maintenance dose makes the most sense for me right now
Patients should work with their healthcare provider to make a shared treatment plan
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