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For perimenopausal women already managing progesterone insufficiency, this adds another layer of disruption that may be mistaken for disease progression rather than metabolic stress

13 As with joint hypermobility, hypermobility spectrum disorders can be subcategorised into: Generalised HSD (G-HSD) : symptomatic generalised joint hypermobility Peripheral HSD (P-HSD): symptomatic peripheral joint hypermobility (hands/feet) Localised HSD (L-HSD): symptomatic localised joint hypermobility, and Historical HSD (H-HSD): Historical joint hypermobility with musculoskeletal symptoms

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Tirzepatide, due to its dual mechanism of action, may lead to enhanced weight loss

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