Combined use has not been extensively studied in Phase III randomized controlled trials, making evidence-based dosing recommendations difficult
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Next, we examined whether reduced HGP in Dpp4 hep/ mice is mediated by DPP4s action on GLP-1 receptor (GLP-1R) signaling
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The preliminary cardiovascular safety data for DPP-4 inhibitors are promising, and, if the results of long-term cardiovascular studies demonstrate reductions in hard cardiovascular end points, then this may consolidate the position of the DPP-4 inhibitors as the second-line choice for combination with metformin
Interpret the clinical evidence for GLP-1-based therapies using major outcomes and biomarkers, including HbA1c, weight loss, and different assessments of cardiometabolic risk
