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Seek same-day medical assessment if you develop sudden, severe joint pain, particularly if accompanied by redness, swelling, or fever, to exclude septic arthritis and receive appropriate treatment

Moreover, the side effects of these medications can be severe: pancreatitis, bowel obstruction, gastroparesis, nausea & vomiting, diarrhea as well as dietary insufficiencies

Science 347 , 12531256 (2015)

Advise patients that changes in insulin regimen can predispose to hyperglycemia or hypoglycemia and that changes in insulin regimen should be made under close medical supervision [see WARNINGS AND PRECAUTIONS ]

doi: 10.1073/pnas.1711235114 47 HeBHoangTKTianXTaylorCMBlanchardELuoMet al

Considering the totality of evidence from clinical trials, post-marketing reports and observational studies, alongside the generally low incidence rate of NAION, Novo Nordisk believes that the benefit-risk profile of semaglutide remains favorable, the spokesperson said.