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1 Practical differences Needles vs tablets The most obvious difference

step-c) Fmoc-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-VaI-Ser(Oxa)-OH (fragment-2) was condensed with peptide obtained from step-b) in presence of a coupling agent to obtain Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-VaI-Ser(Oxa)-Ser(tBu)-Tyr(tBu)-Leu-Glu(OtBu)- Gly-Gln(Trt)-Ala-Ala-Lys(C18 diacid mono-t-butyI-y-Glu(AEEA-AEEA)-OtBu)-Glu(OtBu)- Phe-Ile-Ala-Trp (Boc)-Leu-Val-Arg (pbf) Gly-Arg (pbf)-Gly-O Coupling agent used in the reaction is EDC.HC1 and HOBt in DCM

Besides this, semaglutide is not usually recommended for use in pregnant or breastfeeding women due to the limited data on its safety in these populations

This is highly unsafe

however, it is only approved for type 2 diabetes mellitus in conjunction with exercise and a healthy diet