Common symptoms include: Persistent fatigue and weakness Pale or jaundiced skin Heart palpitations and shortness of breath Nerve problems such as numbness or tingling Cognitive disturbances such as memory loss Glossitis and mouth ulcers High homocysteine levels, leading to cardiovascular issues Given the severe symptoms associated with Vitamin B12 deficiency, timely and effective treatment becomes essential
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Long-term use of metformin or proton pump inhibitors (PPIs) impairs B12 absorption over time
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It is also vital for red blood cell health, energy production and DNA replication and repair and has a role to play in breaking down the amino acid homocysteine, high levels of which have been linked to an increased risk of heart disease, stroke and dementia
Inhibiting it with 5-Amino-1MQ slows energy/repair declines.[6][7][29] As a NAD+ drain, targeting NNMT preserves it, supporting mitochondrial health and longevity protocols