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102 P38 activates mitogen-activated protein kinase (MAPK) pathway to promote neuronal cell death, and microglia activation

Positive outcomes were consistent across the evidence base we reviewed, however, some of the included studies showed a potentially significant overlap, which limits the overall level of evidence

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Some of these include genetics, age, race, diet, physical activity, mental health, and lifestyle choices

The mechanism: lipedema adipocytes exhibit reduced hormone-sensitive lipase (HSL) activity and elevated aromatase expression, creating a depot that preferentially stores fat even during energy deficit

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