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Manual model building and structure refinement were carried out with PHENIX (version 1.20.1-4487) 29 , Coot (version 0.9.6) 30 and phenix-refine, respectively

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90,91 Moreover, epidemiologic studies of different institutions showed that individuals with regular exercise, healthy diet (including more soluble fiber, colorful fruit, vegetables, green tea, or less intake of added sugars, carbs, trans-fats), limiting alcohol intake, avoiding smoking cigarettes and reduced levels of stress, which indeed increase insulin sensitivity