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Hunger JM, Major B, Blodorn A, Miller CT

To report SUSPECTED ADVERSE EVENTS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA-1088 or for voluntary reporting of adverse reactions

[1] Pharmaceutical scientists saw a treatment opportunity

This snowball effect can disrupt a cells integrity, causing it to behave abnormally

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Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility