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Genetics Those born with structural deformities in their spine also have the tendency of the spinal canal to narrow, and thus lead to spinal stenosis

Sikiri P, Petek M, Ruman R, Seiwerth S, et al

A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohns disease

Some patients with certain genetic profiles may experience faster weight loss or more pronounced metabolic shifts, which could increase the risk of secondary muscle symptoms like cramping

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However, the rate of weight loss will likely be slower and less consistent compared to those who combine the medication with regular physical activity