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The thresholds reported in preclinical literature vary: PCB-157 : 10 g/kg to 1 mg/kg subcutaneously or intraperitoneally depending on the model

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A prescriber may consider: BMI and weight-related health risk previous weight-management attempts existing medical conditions current medicines pregnancy plans gastrointestinal health history of pancreatitis or gallbladder problems kidney and liver function diabetes treatment eating-disorder history ability to attend monitoring and follow-up NHS access is more restricted than general private eligibility