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Recent study have found that p53 is involved in ferroptosis, which inhibits cystine uptake by inhibiting the expression of SLC7A11 and sensitizing cells to ferroptosis [27]

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Additionally, activated GPER can upregulate glucose transporters (GLUTs) and hexokinase (HK), increasing the level of aerobic glycolysis and leading to the accumulation of metabolic waste products, including lactic acid, which helps tumor cells evade immune surveillance and enhances their invasive capabilities [6, 34]

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Yang S-J, Xiong YQ, Yeaman MR, Bayles KW, Abdelhady W, Bayer AS