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Notably, compound 30 (Figure 5) exhibited strong activity, with 56.8% inhibition at 10 M

The structure comprises the typical GST fold with an N-terminal thioredoxin-like domain ( 1 1 2 2 3 4 3 ) and an all-helical C-terminal domain ( 4 5 6 7 8 )

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(2018) 315:H133240

196-198 Neramexane, an investigational NMDA blocker, was found in a randomized placebo-controlled trial to reduce scores on the Tinnitus Handicap Inventory questionnaire, but not tinnitus loudness