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At the highest doses used for obesity treatment (2.4 mg semaglutide, 15 mg tirzepatide), the medication may overwhelm certain regulatory mechanisms and produce paradoxical sensitization
Conclusions For patients who have had insufficient weight loss or weight recurrence following sleeve gastrectomy, conversion to RYGB offers greater, long-term weight loss compared to GLP1-RAs
Selected Research References Pickart L, Vasquez-Soltero JM, Margolina A
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