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Therefore, we sought to objectively evaluate the efficacy and safety of 10 globally approved and marketed GLP-1RAs in combination with metformin for treating patients with T2DM through NMA and to provide evidence-based support and reference for the clinical selection of GLP-1RAs

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These medicines mimic the action of naturally occurring GLP-1, a hormone produced in the intestine that plays a crucial role in regulating blood glucose levels and appetite

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A small randomized, double-blind trial that compared a high-fat with a high-carbohydrate hypercaloric diet and an isocaloric control diet reported more adverse events during the 6-months high-fat hypercaloric diet, including weight loss (167)

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