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Constipation, interestingly, shows relatively flat rates across doses, with relative risks around 4.17 to 4.41 regardless of dose level
10.1016/j.lfs.2004.08.010 71 TudorM.JandricI.MarovicA.GjurasinM.PerovicD.RadicB.et al (2010)
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The long-term safety and sustained efficacy of PT-141 was demonstrated in the 52-week open-label extension of the RECONNECT trials
Oxidation of malate, catalyzed by malate dehydrogenase, finally regenerates oxaloacetate, and the cycle continues