The goal of the present study was to determine the effectiveness of repeated 5-day semaglutide treatment on cocaine-vs-food choice in male and female rats using experimental designs demonstrated to enhance translational validity [8]
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In a rat model of migraine, trigeminal neurons have been shown to have abnormal mitochondrial biogenesis capacity represented by the decreased mitochondrial DNA number of copies as well as the altered mRNA levels of peroxisome proliferator-activated receptor-gamma coactivator-1a (31), an essential regulatory factor in mitochondrial biogenesis (32)
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