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Its short action allows dosing around meals instead of continuous all-day stimulation

The potency of PF-06882961 (CS EC 50 = 13 nM) on the cAMP pathway was approximately 120- and 14-fold (Fig 3A, Table S2) lower than exenatide (CS EC 50 = 0.11 nM) and liraglutide (CS EC 50 = 0.95 nM), respectively

Peak areas were integrated using the AB SCIEX MultiQuant 3.0.2 software

Semaglutides Boxed Warning The FDA has issued a boxed warning for semaglutide regarding a potential increased risk of thyroid C-cell tumors

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Another 5% is excreted unchanged