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The BCS approach classifies drugs by their aqueous solubility and intestinal permeability into four groups: Class I: high solubility, high permeability

Synergistic Potential: Can They Be Combined

Thiazides act on the distal tubule

In fact, many of the most vulnerable do not, Connolly points out

If not treated, intestinal obstructions could cause death of the surrounding intestinal tissue and infection of the abdominal cavity (peritonitis)

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