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These symptoms occur as the brain adjusts to lower dopamine and norepinephrine levels after prolonged Adderall use

doi: 10.2147/PPA.S90842 Johnston SS, Nguyen H, Felber E, et al

Nature Medicine, 30(7), 20372048.

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Studies have demonstrated that microbiota-derived SCFAs serve as natural ligands for free fatty acid receptors 2/3 (FFAR2/3), activating signaling pathways in enteroendocrine cells, immune cells, and other cell types ( 3.1.3 Microbial metabolism of dietary fiber, protein, and fat Dietary fiber metabolism: non-digestible carbohydrates represent the primary fermentation substrates for gut bacteria