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This study provides important information by demonstrating, both in vitro and in vivo in mice, that lipotoxicity alters incretin signalling via reductions in receptor levels

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As with any peptide or hormone-based treatment, side effects such as nausea, increased freckles or mole changes, and flushing can occur

Many patients reach a weight loss plateau after 12-18 months on GLP-1 therapy, and this stabilization period often corresponds with natural hair recovery as the metabolic stress diminishes

Metronidazole, trimethoprim-sulfamethoxazole, and tetracycline antibiotics also show no major safety concerns when taken with semaglutide