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However, no clinical trials support concurrent use, and most specialists would likely recommend starting with a single proven agent or an evidence-based dual-compound like tirzepatide before exploring off-label combinations

The strongest biologic rationale involves tissue repair, muscle regeneration, satellite cells, and local growth-factor signaling, but the clinical benefit of PEG-MGF itself remains unestablished [7] [8] [10]

Furthermore, these alterations can establish a substrate for electrical arrhythmias (Sakata et al., 1989

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Gastaldelli A, Cusi K (2019) From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options