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Both p53 TAD PEP and CAND showed limited efficacy in inducing cell death in both dividing and senescent cells (Figure

Hyperinsulinemia and chronic inflammation, common in insulin resistance and type 2 diabetes, promote the overexpression and secretion of endothelin-1 (ET-1), a potent endothelium-derived vasoconstrictor

Most clinically important overlap: Candida overgrowth is a primary cause of intestinal hyperpermeability (leaky gut), which in turn drives systemic inflammation, food intolerances, and autoimmune activation

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Med 115 , 92104 (2017)

In a given dynamic, this underlying bidirectional feedback mechanism plays the directing role in the systemic skeletal remodeling (238)