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doi: 10.1126/science.7973727

89 This hypermetabolic bone state peaks at 12 months (CTX + 200%) and remains elevated above preoperative levels through 24 months

FDA 510k submission For Medical Devices Anyone who wants to sell a medical device in the USA is required to make a FDA 510k submission at least 90 days before offering the device for sale, even though it may have been under development or clinical investigation before that date

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