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No clinically meaningful changes in vital signs or in ECG (including in QTc interval) were observed with the combination of sitagliptin and metformin

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are the two most important hormones and both are thought to contribute equally to the effect

Matching variables included index year, sex, age, diabetes duration, health screening variables (BMI, fasting glucose level, eGFR, smoking habit, alcohol consumption, and number of health screening examinations), comorbidities, and antidiabetic drugs

The most common issues are gastrointestinal side effects

The FDA has received reports that some compound pharmacies have been using salt forms of semaglutide which contain different active ingredients than the FDA-approved medications