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Although ECSOD also utilizes copper and zinc as catalytic cofactors in a similar fashion as CuZnSOD, ECSOD is the only isoform of SOD that is expressed extracellularly and is distributed in the extracellular matrix of many tissues 11 , 12

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This is more obvious in the more sun-exposed parts like the face, neck, dcollet, arms and feet

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Springer Swaminathan S, Dehghan M, Raj JM, Thomas T, Rangarajan S, Jenkins D, Mony P, Mohan V, Lear SA, Avezum A (2021) Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study: prospective cohort study

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