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In the perspective of protective mechanisms of aging cardiomyocytes, inhibition of BMAL1/Clock by NAD+ reduced NF-B binding to DNA, which further decreased the formation of pro-inflammatory mediators and improved mitochondrial function [23]

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doi: 10.3389/fneur.2019.00345 274 SahP

Dysregulation of the innate immune system has been shown to underlie several chronic diseases, including cancer, heart disease, diabetes, Alzheimers, and gut-related disorders